Chinese scientists have made a pivotal breakthrough by identifying a mutation that supercharged the Ebola virus’s transmission during the devastating DRC outbreak from 2018 to 2020. Detailed in Cell, the study highlights how viral evolution can prolong epidemics.
This outbreak, claiming over 2,000 lives from more than 3,000 infections, challenged global response efforts. Beyond infrastructure woes, the virus itself evolved in dangerous ways.
Leading the research, Professor Qian Jun of Sun Yat-sen University analyzed 480 genomes. They discovered the GP-V75A mutation in the glycoprotein, which quickly outpaced the original strain.
‘Viral mutations like this act as hidden accelerators in outbreaks,’ Prof. Jun explained. ‘A decade of Ebola research led us to this pattern.’
In vitro and animal tests showed enhanced cellular entry and infection rates. Worse, GP-V75A evaded some existing antibodies and drugs, potentially fostering resistance.
Experts hail this as a wake-up call for ongoing surveillance. Real-time genome sequencing can flag risks, refine vaccines, and safeguard public health against evolving pathogens.